I am sure it has be researched many times. Have you done a lit dig out yet? http://medlineplus.gov/ http://www.ncbi.nlm.nih.gov/entrez/query.
I'm sure it's be done. Nurses have to assess that every 2-4 hours on adjectives patients who aren't awake and oriented and adjectives patients who are sedated. Nursing flow sheets also have an explanation of the numbers on them. It's really self-explanatory
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