gold is a 'Disease Modifying Antirheumtic drug'
contained by olden days it was the most effectiveagent for arresting rheumatod process and preventing involvement of auxiliary joints 1/2 patints may hold remission of the disease
reduces chemotaxis,phagocytosis,macrop. and lysosomal diversion monocyte differentiation and inhibits cell mediated imperviousness but exact mechanism is unknown rf and esr level are lowered effctive in psoriatic arthropathy also.
indicated surrounded by rapidly progressive forms of RA
benifit after 4-6 weeks
used as AUROTHIOMALATE SODIUM
heavily bound to the plasma protein and remains within the blood for years
high toxcity :vasodilatation
postural hypotension
dermatitis
pruritic imprudent
stomatitis
exfoliative dermatitis(rare)
albuminuriasecondary to membranous glmorulonephritis (10%
)resolves on stopping the drug
hepatitis
peripheral neuritis
encephalopathy
pulmonary fibrosis
eosinophilia
I don't infer your question. However Auranofin, a drug that contains gold ingots has be used to treat arthritis. I do not know what effect it has on the liver. None too well brought-up, perhaps.
Thursday, September 23, 2010
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